Ha. Bazan et al., PATTERNS OF CCR5, CXCR4, AND CCR3 USAGE BY ENVELOPE GLYCOPROTEINS FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PRIMARY ISOLATES, Journal of virology, 72(5), 1998, pp. 4485-4491
Coreceptor usage by Envs from diverse primary human immunodeficiency v
irus type 1 isolates was analyzed by a vaccinia virus-based expression
and assay system. Usage of recombinant CCR5 and CXCR4 correlated clos
ely with fusogenicity toward macrophages and T-cell lines expressing e
ndogenous coreceptors. Surprisingly, recombinant CCR3 was utilized by
most primary and T-cell-line-adapted Envs. Endogenous CXCR4 in macroph
ages was functional as a coreceptor.