PATTERNS OF CCR5, CXCR4, AND CCR3 USAGE BY ENVELOPE GLYCOPROTEINS FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PRIMARY ISOLATES

Citation
Ha. Bazan et al., PATTERNS OF CCR5, CXCR4, AND CCR3 USAGE BY ENVELOPE GLYCOPROTEINS FROM HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 PRIMARY ISOLATES, Journal of virology, 72(5), 1998, pp. 4485-4491
Citations number
53
Categorie Soggetti
Virology
Journal title
ISSN journal
0022538X
Volume
72
Issue
5
Year of publication
1998
Pages
4485 - 4491
Database
ISI
SICI code
0022-538X(1998)72:5<4485:POCCAC>2.0.ZU;2-U
Abstract
Coreceptor usage by Envs from diverse primary human immunodeficiency v irus type 1 isolates was analyzed by a vaccinia virus-based expression and assay system. Usage of recombinant CCR5 and CXCR4 correlated clos ely with fusogenicity toward macrophages and T-cell lines expressing e ndogenous coreceptors. Surprisingly, recombinant CCR3 was utilized by most primary and T-cell-line-adapted Envs. Endogenous CXCR4 in macroph ages was functional as a coreceptor.