SCRUB TYPHUS ASSOCIATED WITH MULTIORGAN FAILURE - A CASE-REPORT

The spectrum of clinical severity for scrub typhus ranges from inappar ent, mild, to severe or fatal. The pathologic changes are focal or dis seminated multiorgan vasculitis of the small blood vessels, a fact tha t helps explain the great diversity of clinical manifestations that ca n be encountered. We reported a case of scrub typhus with unusual and serious multiorgan involvement, including tubulointerstitial nephritis (TIN) with acute renal failure (ARF), interstitial pneumonitis with a dult respirator distress syndrome (ARDS), disseminated intravascular c oagulation (DIC), liver function impairment, upper gastrointestinal bl eeding, prolonged hyperamylasaemia and hyperlipasaemia. Chloramphenico l administration rapidly altered the clinical course, but with sequela e of renal impairment and prolonged hyperamylasaemia and hyperlipasaem ia for 10 months.