IMPROVED DISSOLUTION RATE OF INDOMETHACIN BY ADSORBENTS

Samples of indomethacin and kaolin or microcrystalline cellulose (Avic el) were prepared by solvent deposition or simple blending methods. Di ssolution rates of these samples were studied. The surface adsorption of indomethacin on the studied adsorbents was shown to improve the dis solution rate of the drug in water. The solvent-deposited samples of i ndomethacin on kaolin or Avicel in the ratio 1:4 released 25% of the d rug at 34 or 60 min, respectively (t(25%)), while 25% of the pure drug tvas released at 140 min. Meanwhile, the t(25%) of the corresponding drug-adsorbent simple blends were 108 and 110 min, respectively. The e ffect of addition of polyvinyl pyrrolidone (PVP) as a third component to indomethacin-adsorbent was studied and showed further improvement i n in vitro availability of the drug-kaolin adsorbents.