IN-VITRO RELEASE OF AMOXICILLIN FROM LIPOPHILIC SUPPOSITORIES

The in vitro release characteristics of amoxycillin from different lip ophilic suppository bases were investigated using the USP rotating bas ket method. Suppositories containing 250 mg amoxycillin were prepared in theobroma oil and in the semisynthetic bases Witepsol W35, Suppocir e A32, Novata BD,and Novata 299. Both freshly prepared and 1-month-old suppositories were tested. Analysis of amoxycillin was performed usin g a validated high-performance liquid chromatographic (HPLC) technique . Release profiles differed significantly between bases, with the grea test amount of amoxycillin being released from both newly made and I-m onth-old Novata ED bases (87.57 +/- 8.18 and 99.66 +/- 6.63%, respecti vely), and the lowest amount released from the newly manufactured theo broma suppositories (8.82 +/- 0.75%) and the 1-month-old Suppocire A32 suppositories (7.78 +/- 0.27%).