SYNTHESIS OF ANTINEOPLASTON A10 ANALOGS AS POTENTIAL ANTITUMOR AGENTS

Several aniline mustard analogues were obtained by introducing N,N-bis (2-chloroethyl)amino moiety to phenyl ring of A10 analogues in order t o increase reactivity of A10 analogs and selectivity into DNA. The in vitro antitumor activity oi synthesized compounds was evaluated using five different solid tumor cell lines by SRB method. Aniline mustard a nalogues exhibited more potent antitumor activity than A10 analogs. Es pecially, m-aniline mustard of benzoyl analogue displayed remarkable a ntitumor activity.