EPOXYALKANOYLS AS NOVEL ACE-INHIBITORS

Authors
CHOO HYP YOON HR PARK HS KIM DH PARK J KIM J
Citation
Hyp. Choo et al., EPOXYALKANOYLS AS NOVEL ACE-INHIBITORS, Archives of pharmacal research, 21(2), 1998, pp. 168-173
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Archives of pharmacal research → ACNP
ISSN journal
02536269
Volume
21
Issue
2
Year of publication
1998
Pages
168 - 173
Database
ISI
SICI code
0253-6269(1998)21:2<168:EANA>2.0.ZU;2-Q
Abstract
The epoxyalkanoyl derivatives were designed and synthesized as ACE inh ibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on a ngiotensin converting enzyme was IC50 values of 0.06 similar to 5.5 mu M.