SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF SUBSTITUTED ISOQUINOLINE ANALOGS AS ANTITUMOR AGENT

Authors
CHEON SH PARK JS CHUNG BH CHOI BG CHO WJ CHOI SU LEE CO
Citation
Sh. Cheon et al., SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP STUDIES OF SUBSTITUTED ISOQUINOLINE ANALOGS AS ANTITUMOR AGENT, Archives of pharmacal research, 21(2), 1998, pp. 193-197
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Archives of pharmacal research → ACNP
ISSN journal
02536269
Volume
21
Issue
2
Year of publication
1998
Pages
193 - 197
Database
ISI
SICI code
0253-6269(1998)21:2<193:SASRSO>2.0.ZU;2-0
Abstract
A number of substituted isoquinolin-1-ones, possible bioisosteres of t he 5-aryl substituted 2,3-dihydroimidazo[2,1 -a]isoquinolines, were sy nthesized and tested for their antitumor activity against five differe nt human tumor cell lines. O-(3-hydroxypropyl) substituted compound (1 5) exhibited the best antitumor activity which is 3-5 times better tha n 5-[4'-(piperidinomethyl) phenyl]-2,3-dihydroimidazo [2,1-a]isoquinol ine (1).