FINE-NEEDLE ASPIRATION CYTOLOGY OF GLYCOGEN-RICH CLEAR-CELL CARCINOMAOF THE BREAST - A CASE-REPORT

BACKGROUND: Glycogen-rich clear cell carcinoma (GRCC) is a rare varian t of breast carcinoma that was first described by Hull et al in 1981. The histologic findings have been described; however, the cytologic ch aracteristics have not been well described. CASE: A 44-year-old female exhibited a palpable mass in her right breast. The fine needle aspira te contained cell clusters in a necrotic background. In addition to ca rcinoma cells with increased degrees of nuclear atypia, carcinoma cell s with less atypia were identified. The tumor-cells contained small ro und or ovoid nuclei and abundant, clear cytoplasm. The tumor, resected by modified radical mastectomy, was diagnosed as GRCC with detection of glycogen accumulation in the cytoplasm. CONCLUSION: Although rare, glycogen-rich clear cell carcinoma should be considered in the differe ntial diagnosis of breast cancer in fine needle aspiration cytology to prevent misdiagnosis because of its varied morphologic patterns and l ess atypical cytologic features.