LEUKOCYTE DISTRIBUTION DURING SEVOFLURANE ANESTHESIA

We have examined if sevoflurane anaesthesia per se modified the number of circulating leucocytes in humans. Fifty-nine patients undergoing e lective surgery were anaesthetized with sevoflurane in oxygen. The inh aled concentration was increased gradually to 5% and maintained for 20 min. Arterial blood samples were obtained before induction of anaesth esia and at 20 min. While the total number of leucocytes remained cons tant, circulating neutrophils decreased (mean 3370 (so 1030) mm(-3) to 3170 (940) mm(-3); P<0.01) and lymphocytes increased (1870 (520) mm(- 3) to 2040 (580) mm(-3); P<0.01). We conclude that high concentrations of sevoflurane modified the distribution of leucocytes in anaesthetiz ed patients.