NODULAR LOCALIZED CUTANEOUS AMYLOIDOSIS - FURTHER DEMONSTRATION OF MONOCLONALITY OF INFILTRATING PLASMA-CELLS IN 4 ADDITIONAL JAPANESE PATIENTS

Nodular localized cutaneous amyloidosis (NLCA) is a disorder character ized by deposition of amyloid derived from immunoglobulin light chains . We used semi-nested polymerase chain reaction (PCR) to analyse archi val paraffin-embedded sections from a previous patient and from four a dditional, previously reported patients with NLCA to determine whether involvement of monoclonal plasma cells is a universal feature of this condition. The semi-nested PCR analysis revealed one or two amplified bands, around 100-120bp, for all five cases of NLCA, although the yie lds varied from case to case. These results suggest that clonal expans ion of plasma cells in NLCA may occur locally.