Nodular secondary syphilis in a 23-year-old Indian man was characteriz
ed by numerous papular, nodular and plaque skin lesions, without invol
vement of the mucous membranes, The histopathology showed sarcoid-like
granulomata with lymphocytes, histiocytes, eosinophils, plasma cells
and multinucleated giant cells. The differential diagnosis included de
ep mycoses, leprosy tuberculosis, sarcoidosis and lymphoma. The result
s of serological tests and the rapid response to penicillin indicated
a correct diagnosis.