RESEARCH ON HETEROCYCLIC-COMPOUNDS - PART-XXXIX - 2-METHYLIMIDAZO[1,2-A]PYRIMIDINE-3-CARBOXYLIC DERIVATIVES - SYNTHESIS AND ANTIINFLAMMATORY ACTIVITY

The synthesis of a group of 2-methylimidazo[1,2-a]pyrimidine-3-carboxy lic esters, acids and amides is described. The structures of new compo unds are supported by H-1 and C-13 NMR spectre. These compounds were t ested in vivo for their antiinflammatory, analgesic. and ulcerogenic a ctivity. Eight new compounds out of fifteen showed remarkable dose-dep endent antiinflammatory action in the carrageenan rat paw edema (1/2-1 /3 x indomethacin) but weak analgesic activity in the acetic acid writ hing test together with negligible ulcerogenic action. The new compoun ds were found to be lacking in inhibitory activity on cyclooxygenase i n vitro. (C) Elsevier, Paris.