IMIDAZO[1,2-C]QUINAZOLINES WITH LIPID-PEROXIDATION INHIBITORY EFFECT

Authors
DOMANY G GIZUR T GERE A TAKACSNOVAK K FARSANG G FERENCZY GG TARKANYI G DEMETER M
Citation
G. Domany et al., IMIDAZO[1,2-C]QUINAZOLINES WITH LIPID-PEROXIDATION INHIBITORY EFFECT, European journal of medicinal chemistry, 33(3), 1998, pp. 181-187
Citations number
33
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
33
Issue
3
Year of publication
1998
Pages
181 - 187
Database
ISI
SICI code
0223-5234(1998)33:3<181:IWLIE>2.0.ZU;2-T
Abstract
A series of imidazo[1,2-c]quinazolines of different lipophilic charact er was prepared. According to their antioxidant (cyclic voltammetry) p roperties they all should be potent inhibitors of lipid peroxidation. Under the given circumstances (NADPH-induced lipid peroxidation in rat brain microsomes and Fe2+-induced lipid peroxidation in rat brain hom ogenate), however, their lipid peroxidation inhibitory activity was st rongly dependent on their lipophilicity. (C) Elsevier, Paris.