HIV HYPERIMMUNE GLOBULIN OR INTRAVENOUS IMMUNE GLOBULIN INHIBITS RESPONSE TO AN HIV VACCINE

The murine model was developed to assess the effects of maternally tra nsferred HIV hyperimmune globulin or human intravenous immune globulin on the immunization of the offspring at 18-21 days of age with rgp120 (SF2)-complete Freund's adjuvant, Either HIV hyperimmune globulin or i ntravenous immune globulin was administered intraperitoneally to post- partum BALB/c mice and was transferred via milk to the offspring, Both HIV hyperimmune globulin and intravenous immune globulin inhibited th e offspring anti-rgp120(SF2) IgG response to the vaccine. The HIV hype rimmune globulin inhibition persisted for 28 days after immunization w hile the intravenous immune globulin inhibition was still present at 6 3 days after immunization, In addition, the intravenous immune globuli n had a more generalized immunosuppressive effect, inhibiting the IgG response to both rpg120(SF2) and an additional protein antigen, hen eg g-white lysozyme, Effects of maternal or exogenously administered pre- existing antibody, including control antibodies (intravenous immune gl obulin), on the newborn response to HIV and other vaccines must be car efully evaluated when vaccine studies proceed in newborns.