TRANSCRIPTIONAL REGULATION DURING B-CELL DEVELOPMENT

Information is increasingly available concerning the molecular events that occur during primary and antigen-dependent stages of B cell devel opment. In this review the roles of transcription factors and coactiva tors are discussed with respect to changes in expression patterns of v arious genes during B cell development. Transcriptional regulation is also discussed in the context of developmentally regulated immunoglobu lin gene V(D)J recombination, somatic hypermutation, and isotype switc h recombination.