MYCOBACTERIUM-LEPRAE BINDS TO A 25-KDA PHOSPHORYLATED GLYCOPROTEIN OFHUMAN PERIPHERAL-NERVE

Authors
SUNEETHA LM SATISH PR KORULA RJ SUNEETHA SK JOB CK BALASUBRAMANIAN AS
Citation
Lm. Suneetha et al., MYCOBACTERIUM-LEPRAE BINDS TO A 25-KDA PHOSPHORYLATED GLYCOPROTEIN OFHUMAN PERIPHERAL-NERVE, Neurochemical research, 23(6), 1998, pp. 907-911
Citations number
33
Categorie Soggetti
Biology,Neurosciences
Journal title
Neurochemical research → ACNP
ISSN journal
03643190
Volume
23
Issue
6
Year of publication
1998
Pages
907 - 911
Database
ISI
SICI code
0364-3190(1998)23:6<907:MBTA2P>2.0.ZU;2-E
Abstract
Mycobacterium leprae, the causative agent of leprosy, specifically inv ades and destroys the peripheral nerve, which results in the main clin ical manifestation of the disease. Little is known about the bacteria- nerve protein interaction. We show in the present work that M leprae b inds to a 25 kDa glycoprotein from human peripheral nerve. This protei n is phosphorylatable and it binds to lectins which have alpha-mannose specificity. This M leprae-protein interaction could be of importance in the pathogenesis of leprosy.