Rationale and Objectives. The authors developed a technique to produce
high-resolution, three-dimensional images of vasculature from a set o
f x-ray projections in an attempt to provide detailed anatomic represe
ntations of complex vasculature. Materials and Methods. Projection ima
ges were acquired with a clinical angiographic system by using biplana
r rotation digital subtraction angiography. The images were reconstruc
ted with an additive algebraic reconstruction technique. Results. The
feasibility of the technique was tested by reconstructing three-dimens
ional images of several phantoms, including a wire phantom and an anat
omic flow phantom. The anatomy phantom allowed replication of contrast
material flow and image noise that are characteristic of patient exam
inations. The reconstruction procedure was then used to examine a caro
tid artery and a cerebral aneurysm in two patients. Conclusion. A meth
od of reconstructing vasculature from x-ray angiograms has been develo
ped and validated with geometric and anatomic phantoms. Preliminary pa
tient applications indicate that this technique enables enhanced visua
lization of complex vascular relationships and structures.