Rb. Turner et al., ASSOCIATION BETWEEN INTERLEUKIN-8 CONCENTRATION IN NASAL SECRETIONS AND SEVERITY OF SYMPTOMS OF EXPERIMENTAL RHINOVIRUS COLDS, Clinical infectious diseases, 26(4), 1998, pp. 840-846
The purpose of this study was to examine the association between exper
imental rhinovirus infection and the elaboration of interleukin-8 (IL-
8) into nasal secretions of volunteers and to determine the effect of
pentoxifylline on IL-8 elaboration and rhinovirus-associated common co
ld symptoms. Fifty-four subjects with experimental rhinovirus infectio
ns and 20 sham-inoculated subjects were studied. Pentoxifylline had no
effect on rhinovirus-induced symptoms or nasal-secretion IL-8 concent
rations. IL-8 concentrations were significantly greater in nasal secre
tions from infected symptomatic subjects than in those from infected a
symptomatic or sham-challenged subjects on days 2-4 after virus challe
nge. In infected subjects, there was significant rank correlation betw
een nasal obstruction severity, rhinorrhea severity, and nasal-wash al
bumin concentrations and the change in IL-8 concentration from baselin
e on days 2-4 after virus challenge.