AN EFFICIENT AND CONVENIENT PROCEDURE FOR THE SYNTHESIS OF N-ALPHA-FMOC-O-MONOBENZYL PHOSPHONOTYROSINE

Authors
HANDA BK HOBBS CJ
Citation
Bk. Handa et Cj. Hobbs, AN EFFICIENT AND CONVENIENT PROCEDURE FOR THE SYNTHESIS OF N-ALPHA-FMOC-O-MONOBENZYL PHOSPHONOTYROSINE, Journal of peptide science, 4(2), 1998, pp. 138-141
Citations number
10
Categorie Soggetti
Biology,"Chemistry Analytical
Journal title
Journal of peptide science → ACNP
ISSN journal
10752617
Volume
4
Issue
2
Year of publication
1998
Pages
138 - 141
Database
ISI
SICI code
1075-2617(1998)4:2<138:AEACPF>2.0.ZU;2-G
Abstract
An efficient procedure is described for the synthesis of N-alpha-Fmoc- O-monobenzyl phosphonotyrosine from the corresponding dibenzyl derivat ive by monodebenzylation in the presence of sodium iodide. A simple wo rk up procedure removes the by-products and the monobenzylated phospho no product is obtained in high yield. (C) 1998 European Peptide Societ y and John Wiley & Sons, Ltd.