REACTION OF 4-BROMOBENZYL-3-METHYL-1,2-OXAZIN-6 ONES WITH PRIMARY ALIPHATIC-AMINES - SYNTHESIS AND STRUCTURAL DETERMINATION OF NEW OXAZINE AND ISOXAZOTE DERIVATIVES

Reaction of 4-bromobenzyl-6 (H) under bar-1,2-oxazin-6-ones (1) with a minoalkylamines furnished a mixture of 5-aminoalkylamino-6 (H) under b ar-1,2-oxazin-6-ones (2), 4-(aminoalkylaminocarbonylmethyl)isoxazoles (3) and 5-(Aminoalkylaminocarbonyl)isoxazoles (4) which were separated by column chromatography. Structure of all derivatives was determined by H-1- and C-13-NMR methods, including INEPT measurements. Structure of isoxazoles (3) and (4) was confirmed by X-Ray analysis. In additio n, test compounds were investigated for analgesic and antidepressant a ctivities in mice.