SYNTHESES OF NOVEL ACYCLIC NUCLEOSIDES, 9-(4'-HYDROXY-2'-METHYLBUT-1'-ENYL)ADENINE AND RELATED-COMPOUNDS

Authors
CHENG CM SHIMO T SOMEKAWA K BABA M
Citation
Cm. Cheng et al., SYNTHESES OF NOVEL ACYCLIC NUCLEOSIDES, 9-(4'-HYDROXY-2'-METHYLBUT-1'-ENYL)ADENINE AND RELATED-COMPOUNDS, Heterocycles, 48(3), 1998, pp. 491-498
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
48
Issue
3
Year of publication
1998
Pages
491 - 498
Database
ISI
SICI code
0385-5414(1998)48:3<491:SONAN9>2.0.ZU;2-L
Abstract
An exploratory coupling reaction between adenine and a protected vicin al dibromo-intermediate was carried out to give the beta,gamma-unsatur ated nucleoside analogues and a vinyl bromide derivative. Then a novel CuI catalytic coupling reaction between adenine and the vinyl bromide was successfully developed to afford an alpha,beta-unsaturated acycli c nucleoside, 9-(4'-hydroxy-2'-methylbut-1'-enyl)adenine. All the abov e nucleosides were subjected to an anti-HIV-1 test.