Cm. Cheng et al., SYNTHESES OF NOVEL ACYCLIC NUCLEOSIDES, 9-(4'-HYDROXY-2'-METHYLBUT-1'-ENYL)ADENINE AND RELATED-COMPOUNDS, Heterocycles, 48(3), 1998, pp. 491-498
An exploratory coupling reaction between adenine and a protected vicin
al dibromo-intermediate was carried out to give the beta,gamma-unsatur
ated nucleoside analogues and a vinyl bromide derivative. Then a novel
CuI catalytic coupling reaction between adenine and the vinyl bromide
was successfully developed to afford an alpha,beta-unsaturated acycli
c nucleoside, 9-(4'-hydroxy-2'-methylbut-1'-enyl)adenine. All the abov
e nucleosides were subjected to an anti-HIV-1 test.