POLYMORPHISM WITHIN THE HLA-DQB1-ASTERISK-02 PROMOTER ASSOCIATED WITHSUSCEPTIBILITY TO CELIAC-DISEASE

Authors
FERNANDEZARQUERO M CALDES T CASADO E MALUENDA C FIGUEREDO MA DELACONCHA EG
Citation
M. Fernandezarquero et al., POLYMORPHISM WITHIN THE HLA-DQB1-ASTERISK-02 PROMOTER ASSOCIATED WITHSUSCEPTIBILITY TO CELIAC-DISEASE, European journal of immunogenetics, 25(1), 1998, pp. 1-3
Citations number
13
Categorie Soggetti
Immunology,"Genetics & Heredity
Journal title
European journal of immunogenetics → ACNP
ISSN journal
09607420
Volume
25
Issue
1
Year of publication
1998
Pages
1 - 3
Database
ISI
SICI code
0960-7420(1998)25:1<1:PWTHPA>2.0.ZU;2-4
Abstract
Susceptibility to coeliac disease is associated with a particular HLA- DQ alpha beta heterodimer encoded by the DQA10501 and DQB1*02 genes. A single base polymorphism in the DQB102 promoter region in DR7, DQA1 0201, DQB1*02 haplotypes was observed, associated with an increased s usceptibility to the disease. This finding suggests a novel mechanism of susceptibility to immune-mediated diseases.