BIODISTRIBUTION AND RADIOIMMUNOPHARMACOKINETICS OF I-131 AMA MONOCLONAL-ANTIBODY IN ATHEROSCLEROTIC RABBITS

Authors
CHAKRABARTI M CHENG KT SPICER KM KIRSCH WM FOWLER SD KELLN W GRIENDE S NEHLSENCANNARELLA S WILLERSON R SPICER SS KOCH T
Citation
M. Chakrabarti et al., BIODISTRIBUTION AND RADIOIMMUNOPHARMACOKINETICS OF I-131 AMA MONOCLONAL-ANTIBODY IN ATHEROSCLEROTIC RABBITS, Nuclear medicine and biology, 22(6), 1995, pp. 693-697
Citations number
12
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging
Journal title
Nuclear medicine and biology
ISSN journal
09698051 → ACNP
Volume
22
Issue
6
Year of publication
1995
Pages
693 - 697
Database
ISI
SICI code
0969-8051(1995)22:6<693:BAROIA>2.0.ZU;2-8
Abstract
Monoclonal antibodies have been raised against Ama isolated from human and experimental atherosclerotic plaque. I-131-Ama-MoAb in the whole antibody form was injected into normal NZW rabbits and Watanabe hyperl ipidemic rabbits. Biodistribution studies showed that atheromatous aor tas hud a significantly higher (5-7X) uptake of I-131-Ama-MoAb than th at of normal aortas. However. I-131-Ama-MoAb was cleared very slowly f rom atherosclerotic rabbits. As a result, atheromas could not be ident ified by imaging because of the low target to non-target ratios.