GRADIENTS OF HLA DIVERSITY IN SOUTH-AMERICAN INDIANS

Authors
ROTHHAMMER F SILVA C CALLEGARIJACQUES SM LLOP E SALZANO FM
Citation
F. Rothhammer et al., GRADIENTS OF HLA DIVERSITY IN SOUTH-AMERICAN INDIANS, Annals of human biology, 24(3), 1997, pp. 197-208
Citations number
62
Categorie Soggetti
Biology,"Public, Environmental & Occupation Heath
Journal title
Annals of human biology → ACNP
ISSN journal
03014460
Volume
24
Issue
3
Year of publication
1997
Pages
197 - 208
Database
ISI
SICI code
0301-4460(1997)24:3<197:GOHDIS>2.0.ZU;2-0
Abstract
Information concerning the HLA-A and -B loci was considered in relatio n to 3796 Amerindians living in 39 places in South America, data relat ed to HLA-C being based on a smaller subset of 2989 persons distribute d among 33 localities. Synthetic gene frequency maps were then constru cted using principal-components analysis. Clearly significant longitud inal (principal component 1) and latitudinal (principal components 1, 2, and 3) dines were observed, most probably indicating ancient migrat ion routes.