BIOCONVERSION OF OPTICALLY-ACTIVE PYRIDYL ALCOHOLS FROM THE CORRESPONDING RACEMATES WITH PLANT-CELL CULTURES

Authors
TAKEMOTO M ACHIWA K
Citation
M. Takemoto et K. Achiwa, BIOCONVERSION OF OPTICALLY-ACTIVE PYRIDYL ALCOHOLS FROM THE CORRESPONDING RACEMATES WITH PLANT-CELL CULTURES, Chemical and Pharmaceutical Bulletin, 46(4), 1998, pp. 577-580
Citations number
20
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
4
Year of publication
1998
Pages
577 - 580
Database
ISI
SICI code
0009-2363(1998)46:4<577:BOOPAF>2.0.ZU;2-P
Abstract
A novel method for producing optically active pyridyl alcohols from th e corresponding racemates was developed. When racemic pyridyl alcohol is incubated with Catharanthus roseus cell cultures, chiral alcohol is obtained in high yield with excellent enantiomeric excess (ee) (derac emization of racemate). Furthermore, the kinetic resolution of racemic pyridyl alcohol via oxidation gave the chiral compound with high ee.