[2-(OMEGA-PHENYLALKYL)PHENOXY]ALKYLAMINES - SYNTHESIS AND DUAL DOPAMINE(2) (D-2) AND 5-HYDROXYTRYPTAMINE(2) (5-HT2) RECEPTOR ANTAGONISTIC ACTIVITIES

Authors
TANAKA N GOTO R ITO R HAYAKAWA M OGAWA T FUJIMOTO K
Citation
N. Tanaka et al., [2-(OMEGA-PHENYLALKYL)PHENOXY]ALKYLAMINES - SYNTHESIS AND DUAL DOPAMINE(2) (D-2) AND 5-HYDROXYTRYPTAMINE(2) (5-HT2) RECEPTOR ANTAGONISTIC ACTIVITIES, Chemical and Pharmaceutical Bulletin, 46(4), 1998, pp. 639-646
Citations number
16
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
4
Year of publication
1998
Pages
639 - 646
Database
ISI
SICI code
0009-2363(1998)46:4<639:[-SADD>2.0.ZU;2-G
Abstract
A series of [2-(omega-phenylalkyl)phenoxy]alkylamines was synthesized and their 5-hydroxytryptamine(2) (5-HT2) and/or dopamine(2) (D-2) rece ptor antagonistic activities were examined in vitro. [2-(4-Phenylbutyl )phenoxy]alkylamines showed strong inhibition of both 5-HT2 and D-2 re ceptors, In particular, [2-(4-phenylbutyl)phenoxy]methylpiperidine der ivatives. 10b, 10i and 10q, exhibited potent inhibition. The structure -activity relationships in this series of compounds are discussed.