SOLUTION CONFORMATION OF GINSENG TETRAPEPTIDE H-L-VAL-GAMMA-D-GLU-D-ARG-GLY-OH

Authors
ISHIZU T FUJIWARA M YAGI A NOGUCHI S
Citation
T. Ishizu et al., SOLUTION CONFORMATION OF GINSENG TETRAPEPTIDE H-L-VAL-GAMMA-D-GLU-D-ARG-GLY-OH, Chemical and Pharmaceutical Bulletin, 46(4), 1998, pp. 690-692
Citations number
15
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
4
Year of publication
1998
Pages
690 - 692
Database
ISI
SICI code
0009-2363(1998)46:4<690:SCOGTH>2.0.ZU;2-9
Abstract
The ginseng tetrapeptide H-L-Val-gamma-D-Glu-D-Arg-Gly-OH (1) was synt hesized using a solution-phase methodology, and its solution conformat ion in dimethyl sulfoside (DMSO)-d(6) was determined by a combination of NMR and computational techniques with the DADAS90 program. This com pound has a rigid backbone based on three intramolecular hydrogen bond s between D-Arg NH and L-Val CO, between Gly NH and D-Glu CO, and betw een Gly NH and Gly CO.