ISEPAMICIN-SULFATE-INDUCED SENSORINEURAL HEARING-LOSS IN PATIENTS WITH THE 1555-A-]G MITOCHONDRIAL MUTATION

A mitochondrial mutation at nucleotide 1555 has been reported to be su sceptible to aminoglycoside antibiotics as well as one of the causes o f nonsyndromic sensorineural hearing loss. We herewith report 2 cases bearing the 1555 A-->G mitochondrial mutation who had hearing loss alt er short-term exposure to the new aminoglycoside antibiotic, isepamici n sulfate. Even when using aminoglycoside antibiotics with milder side effects, careful attention should be paid in applying them to patient s with particular genetic backgrounds.