FURTHER IMPLICATIONS OF A COMPUTATIONAL MODEL OF SEPTOHIPPOCAMPAL CHOLINERGIC MODULATION IN EYEBLINK CONDITIONING

Citation
Ce. Myers et al., FURTHER IMPLICATIONS OF A COMPUTATIONAL MODEL OF SEPTOHIPPOCAMPAL CHOLINERGIC MODULATION IN EYEBLINK CONDITIONING, Psychobiology, 26(1), 1998, pp. 1-20
Citations number
102
Categorie Soggetti
Psychology,Psychology
Journal title
ISSN journal
08896313
Volume
26
Issue
1
Year of publication
1998
Pages
1 - 20
Database
ISI
SICI code
0889-6313(1998)26:1<1:FIOACM>2.0.ZU;2-#
Abstract
Previously we have shown that Gluck and Myers's (1993) corticohippocam pal model could be extended to incorporate Hasselmo and Schnell's (199 4) hypothesis that septohippocampal cholinergic processes regulate the amount of information storage in hippocampus. The generalized model c ould account for the effect of the anticholinergic drug scopolamine in delaying onset of eyeblink conditioning (Myers et al., 1996). Here, w e show that the model also accounts for additional eyeblink results, i ncluding quick recovery after scopolamine is removed, preserved latent inhibition, learned irrelevance and extinction under scopolamine, and no effect of systemic scopolamine after hippocampal lesion. Additiona lly, the model is consistent with data concerning localized scopolamin e injections to the medial septum, the lateral septum, and the hippoca mpus and their effect on eyeblink conditioning.