Ce. Myers et al., FURTHER IMPLICATIONS OF A COMPUTATIONAL MODEL OF SEPTOHIPPOCAMPAL CHOLINERGIC MODULATION IN EYEBLINK CONDITIONING, Psychobiology, 26(1), 1998, pp. 1-20
Previously we have shown that Gluck and Myers's (1993) corticohippocam
pal model could be extended to incorporate Hasselmo and Schnell's (199
4) hypothesis that septohippocampal cholinergic processes regulate the
amount of information storage in hippocampus. The generalized model c
ould account for the effect of the anticholinergic drug scopolamine in
delaying onset of eyeblink conditioning (Myers et al., 1996). Here, w
e show that the model also accounts for additional eyeblink results, i
ncluding quick recovery after scopolamine is removed, preserved latent
inhibition, learned irrelevance and extinction under scopolamine, and
no effect of systemic scopolamine after hippocampal lesion. Additiona
lly, the model is consistent with data concerning localized scopolamin
e injections to the medial septum, the lateral septum, and the hippoca
mpus and their effect on eyeblink conditioning.