REMNANT-LIKE PARTICLE CHOLESTEROL MAY INDICATE ATHEROGENIC RISK IN PATIENTS ON CHRONIC-HEMODIALYSIS

Recently, involvement of remnant-like particle cholesterol (RLP-C) in atherosclerosis was reported, but this parameter has not been adequate ly investigated in hemodialysis (HD) patients. The present study inves tigated the relationship between the RLP-C level and total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) , high density lipoprotein cholesterol (HDL-C), lipid peroxides (malon e dialdehyde, MDA), apolipoprotein (Ape) A-I, and ApoB. In addition, t he fractions of very low density lipoprotein (VLDL), intermediate dens ity lipoprotein (IDL), LDL, and HDL in serum lipoproteins were determi ned by disk polyacrylamide gel electrophoresis. The relationship betwe en the RLP-C level and three atherogenic indices was also studied. The RLP-C level in HD patients (8.2 +/- 6.7 mg/dl) was significantly high er than that in normal controls (2.7 +/- 1.3 mg/dl). The RLP-C level s howed a significant positive correlation with the levels of TC, TG, LD L-C, MDA, ApoB, VLDL(%), and IDL(%), as well as a negative correlation with HDL(%). However, there was no correlation with age or the durati on of HD. RLS-C also showed significant positive correlations with the (TC-HDL-C)/HDL-C ratio and the (VLDL + LDL)/HDL ratio, as well as a n egative correlation with the ApoA-I/ApoB ratio. These results suggest that RLP-C may be a potential indicator of atherogenic risk in HD pati ents.