HYPERCOAGULABILITY AND SECONDARY HYPERFIBRINOLYSIS MAY BE RELATED TO ABNORMAL LIPID-METABOLISM IN PATIENTS TREATED WITH CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS

Citation
M. Kobayashi et al., HYPERCOAGULABILITY AND SECONDARY HYPERFIBRINOLYSIS MAY BE RELATED TO ABNORMAL LIPID-METABOLISM IN PATIENTS TREATED WITH CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS, Nephron, 76(1), 1997, pp. 56-61
Citations number
45
Categorie Soggetti
Urology & Nephrology
Journal title
ISSN journal
00282766
Volume
76
Issue
1
Year of publication
1997
Pages
56 - 61
Database
ISI
SICI code
0028-2766(1997)76:1<56:HASHMB>2.0.ZU;2-M
Abstract
To investigate abnormalities in the hemostatic and fibrinolytic system in CAPD patients, parameters of coagulation, anticoagulation, fibrino lysis, and platelet function were measured in 21 CAPD patients and 20 healthy controls. The CAPD patients had significantly higher levels of factor (F) IX, FVII, FX, antithrombin III, thrombin/antithrombin III complex, protein C, protein S, thrombomodulin, fibrinogen, fibrinopept ide A, plasminogen, FXIII, alpha(2)-plasmin inhibitor, alpha(2)-plasmi n inhibitor/plasmin complex, D-dimer, fibrinopeptide B beta 15-42, and beta-thromboglobin than the healthy controls. The CAPD patients also showed a shorter prothrombin time. However, tissue plasminogen activat or, plasminogen activator inhibitor-1 and platelet factor-4 did not sh ow any significant differences from the levels in healthy controls. Th ere was a significant positive correlation between many of the blood p arameters and serum lipids. These results demonstrate that hypercoagul ability and secondary hyperfibrinolysis occur in CAPD patients, and su ggest that these changes may be related to abnormalities in lipid meta bolism.