ANTINUCLEAR ANTIBODIES (ANA) AND COMPLEMENT-FIXING ANA IN SYSTEMIC CONNECTIVE-TISSUE DISEASES

Authors
BEUTNER EH BINDER WL FANG YV PLUNKETT RW RUBIN RL
Citation
Eh. Beutner et al., ANTINUCLEAR ANTIBODIES (ANA) AND COMPLEMENT-FIXING ANA IN SYSTEMIC CONNECTIVE-TISSUE DISEASES, Immunological investigations, 27(1-2), 1998, pp. 97-104
Citations number
16
Categorie Soggetti
Immunology
Journal title
Immunological investigations → ACNP
ISSN journal
08820139
Volume
27
Issue
1-2
Year of publication
1998
Pages
97 - 104
Database
ISI
SICI code
0882-0139(1998)27:1-2<97:AA(ACA>2.0.ZU;2-W
Abstract
Screening for antinuclear antibodies (ANA) with parallel tests for com plement fixing ANA (C-ANA) reveal that C-ANA react either as strongly as or more strongly than ANA in most cases of systemic lupus erythemat osus (SLE) and related disorders including CREST syndrome. But sera of drug induced LE and other ANA positive subjects have weak or no C-ANA . (P < 0.0005). Titrations with parallel C-ANA/ANA tests of two cases reveal primarily ANA and less C-ANA reactions in a case of drug induce d LE but in CREST syndrome both ANA and C-ANA tests yield elevated tit ers with stronger C-ANA reactions. These findings point to distinct im munochemical mechanisms in C-ANA and ANA reactions.