A. Grabowskamaslanka et al., INFLUENCE OF CADMIUM INTOXICATION ON THROMBORESISTANCE OF VASCULAR ENDOTHELIUM IN RABBITS, Journal of Physiology and Pharmacology, 49(1), 1998, pp. 61-69
Here, using our original technique for measuring of thrombogenesis on
the surface of rabbit aorta endothelium superfused with whole blood, w
e demonstrate that the thrombogenic property of endothelium is potenti
ated in the course of 3 months cadmium intoxication. The loss of endot
helial thromboresistance is accompanied by suppressed generation of en
dogenous prostacyclin, leukopenia, increased platelet aggregability an
d by the presence of quasi-atherosclerotic, focal proliferative, glass
y-protein lesions formed in aortic endothelium. We hypothesize that th
e final loss of vessel thromboresistance with all sequence of events t
hat accompany cadmium intoxication, may result from the cadmium-induce
d inhibition of the generation of endothelial prostacyclin. However, t
he exact mechanism by which cadmium intoxication may affect the genera
tion of prostacyclin and, then, functioning of blood platelets and vas
cular endothelium requires further investigations.