Mm. Winnicka, 6-OHDA BILATERAL LESIONS TO THE CENTRAL AMYGDALA DO NOT AFFECT VASOPRESSIN IMPROVEMENT OF RECALL IN RATS, Acta Neurobiologiae Experimentalis, 56(4), 1996, pp. 943-948
The influence of vasopressin (AVP) on recall of information in a passi
ve avoidance situation after bilateral 6-OHDA lesions to the central a
mygdala was tested. AVP given 15 min before the retention testing at t
he icy dose of 1 mu g significantly prolonged avoidance latencies both
in lesioned and in sham-operated rats in comparison with the respecti
ve icy saline injected animals. Insignificant increase of spontaneous
locomotor activity in rats lesioned to the central amygdala was unlike
ly to interfere with the cognitive effect of AVP. These results sugges
t that dopaminergic projection to the central amygdala is not responsi
ble for the facilitatory effect of AVP on retrieval process in a passi
ve avoidance situation.