Latex gloves are in widespread use among preclinical medical and denta
l students in the dissecting room. Increasing numbers of cases of seve
re latex sensitivity are being reported. This study was carried out to
assess the size of this problem among preclinical and clinical studen
ts. First-year students (196) and fifth-year students (155) of the Uni
ted Medical and Dental Schools of Guy's and St. Thomas's Hospitals (UM
DS) were asked to complete a questionnaire about symptoms related to a
llergy to latex gloves and associated risk factors. The prevalence of
all self-reported symptoms was 9.6% overall with no significant differ
ence between first-and fifth-year students. The prevalence of rash was
significantly different: 2.6%, in first-year and 8.5% in fifth-year s
tudents. Of those who reported symptoms, there was a significant exces
s of females and of individuals with eczema,hay fever, or a family his
tory of atopic conditions, compared with those without symptoms. There
was no difference between racial groups and no demonstrable link with
a history of food allergy, previous surgery, or sensitivity to househ
old rubber products. Only 2 of the 29 individuals with symptoms report
ed for skin-prick testing, one of whom demonstrated Type I hypersensit
ivity. (C) 1998 Wiley-Liss, Inc.