FIBROBLAST-GROWTH-FACTOR-2 AND FIBROBLAST-GROWTH-FACTOR-9 REGULATE PROLIFERATION AND PRODUCTION OF MATRIX METALLOPROTEINASES IN HUMAN GLIOMAS

Fibroblast growth factor (FGF) signaling has been recognized in human gliomas. We tested the effect of FGF-2 and FGF-9 on the proliferation and the expression of matrix metalloproteinases (MMPs) and their inhib itor (TIMP-1) in vitro. Both FGFs showed mitogenic activity on U251MG and NMC-G1 cells. MMP-1 expression and collagenolytic activity of NMC- G1 but not of U251MG, and TIMP-1 expression of both cells were stimula ted by FGFs. MMP-2 expression, gelatinolytic activity, and chemo-invas ion on the matrigel were not altered. FGFs may regulate proliferation and microenvironmental factors independently in each glioma type.