MAPPING GENES LOCATED ON HUMAN-CHROMOSOME-2 AND HUMAN-CHROMOSOME-12 TO PORCINE CHROMOSOME-15 AND CHROMOSOME-5

Informative microsatellites associated with two genes on HSA12 (lysozy me, LYZ; tumour necrosis factor receptor, TNFR) and one gene on HSA2 ( glutamic acid decarboxylase 1, GAD1) were mapped in the US Meat Animal Research Center (MARC) swine reference population and the physical as signment of a-lactalbumin (LALBA) was determined. A comparative map fo r HSA2 and HSA12 with SSC15 and SSC5, respectively, was developed by c ombining the results from this study with published type I loci mapped in both species. One rearrangement between HSA2 and SSC15 was detecte d while the number of rearrangements between HSA12 and SSC5 were numer ous. These results indicated that conservation of synteny does not imp ly a conservation of gene order and that additional type I markers nee d to be mapped in the pig to fully understand the chromosomal rearrang ements that occurred during the evolution of mammals.