Since the first report of an aneurysm involving the pancreaticoduodena
l arteries a century ago, only 83 cases have been reported in our coll
ective review of the English literature. Their presentation varies fro
m indistinct abdominal pain to hemorrhagic shock, often making the dia
gnosis onerous. The mortality rate in this patient group has been sign
ificant, and in cases reported since 1980, the mortality rate remains
at 17% (7 deaths/42 reported cases). Surgery has been, and continues t
o be, the cornerstone of therapy, with an incumbent mortality rate of
19% (5 deaths/26 patients treated surgically since 1980). This case re
port and 100-year review of the literature describes the causes, natur
al history, and historic management of pancreaticoduodenal artery aneu
rysms. Most importantly, it demonstrates the use of angiographic embol
ization in the definitive management of these aneurysms with no mortal
ity.