SYNTHESIS AND METAL COMPLEXATION OF CHIRAL 3-MONO-2-HYDROXYPYRROLOPYRAZINE-1,4-DIONES OR 3,3-BIS-ALLYL-2-HYDROXYPYRROLOPYRAZINE-1,4-DIONES

Authors
CHITTARI P JADHAV VR GANESH KN RAJAPPA S
Citation
P. Chittari et al., SYNTHESIS AND METAL COMPLEXATION OF CHIRAL 3-MONO-2-HYDROXYPYRROLOPYRAZINE-1,4-DIONES OR 3,3-BIS-ALLYL-2-HYDROXYPYRROLOPYRAZINE-1,4-DIONES, Journal of the Chemical Society. Perkin transactions. I, (7), 1998, pp. 1319-1324
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
7
Year of publication
1998
Pages
1319 - 1324
Database
ISI
SICI code
0300-922X(1998):7<1319:SAMCOC>2.0.ZU;2-F
Abstract
A novel synthesis of chiral cyclic hydroxamic acids (4, 6, 8 and 10) r elated to cyclodipeptides is described. The crucial reduction of the n itro group of the N-nitroacetyl derivatives of(S)-alpha-amino acid est ers is brought about by zinc-aq. ammonium chloride. The Fe-III and Cu- II complexes of one such cyclic hydroxamic acid 10a have been prepared and their DNAse activity investigated.