FROM CAPPED TO 3-DIMENSIONAL CYCLODEXTRINS - THE FIRST EXAMPLE OF A NEW CLASS OF RECEPTORS BY TREHALOSE CAPPING OF A BETA-CYCLODEXTRIN

Authors
CUCINOTTA V GRASSO G VECCHIO G
Citation
V. Cucinotta et al., FROM CAPPED TO 3-DIMENSIONAL CYCLODEXTRINS - THE FIRST EXAMPLE OF A NEW CLASS OF RECEPTORS BY TREHALOSE CAPPING OF A BETA-CYCLODEXTRIN, Journal of inclusion phenomena and molecular recognition in chemistry, 31(1), 1998, pp. 43-55
Citations number
20
Categorie Soggetti
Chemistry,Crystallography
Journal title
Journal of inclusion phenomena and molecular recognition in chemistry
ISSN journal
09230750 → ACNP
Volume
31
Issue
1
Year of publication
1998
Pages
43 - 55
Database
ISI
SICI code
0923-0750(19980121)31:1<43:FCT3C->2.0.ZU;2-R
Abstract
A new capped derivative of cyclomaltoheptaose (CDTHCM) was synthesized by the reaction of 6,6'-dideoxy-6,6' -di(S-cysteamine)-alpha,alpha'-t rehalose with 6A,6D-dideoxy-6A,6D-diiodo-cyclomaltoheptaose. The CDTHC M obtained was characterized, together with its behaviour towards prot onation. The CDTHCM/ACS (anthraquinone-2-sulfonic acid sodium salt) sy stem was investigated by (HNMR)-H-1 spectroscopy and by i.c.d. (induce d circular dichroism) at two different pHs. The deep inclusion of ACS within the CDTHCM cavity, with an association constant about six times larger compared to the beta-CD/ACS system was found at pH 6.