V. Cucinotta et al., FROM CAPPED TO 3-DIMENSIONAL CYCLODEXTRINS - THE FIRST EXAMPLE OF A NEW CLASS OF RECEPTORS BY TREHALOSE CAPPING OF A BETA-CYCLODEXTRIN, Journal of inclusion phenomena and molecular recognition in chemistry, 31(1), 1998, pp. 43-55
Citations number
20
Categorie Soggetti
Chemistry,Crystallography
Journal title
Journal of inclusion phenomena and molecular recognition in chemistry
A new capped derivative of cyclomaltoheptaose (CDTHCM) was synthesized
by the reaction of 6,6'-dideoxy-6,6' -di(S-cysteamine)-alpha,alpha'-t
rehalose with 6A,6D-dideoxy-6A,6D-diiodo-cyclomaltoheptaose. The CDTHC
M obtained was characterized, together with its behaviour towards prot
onation. The CDTHCM/ACS (anthraquinone-2-sulfonic acid sodium salt) sy
stem was investigated by (HNMR)-H-1 spectroscopy and by i.c.d. (induce
d circular dichroism) at two different pHs. The deep inclusion of ACS
within the CDTHCM cavity, with an association constant about six times
larger compared to the beta-CD/ACS system was found at pH 6.