A report is presented of a patient with neonatal erythema infectiosum
who developed petechiae, transient thrombocytopenia and transient card
iac failure due to transplacental transmission of human parvovirus B19
(HPV B19) infection. It is suggested that the thrombocytopenia was ca
used by platelet-associated IgG produced by the patient, and that the
cardiac failure may have been caused by direct entry of HPV Big into t
he cardiac tissue.