TRANSPORT OF GLUTATHIONE S-CONJUGATES IN ESCHERICHIA-COLI

There are no reports concerning glutathione-S-conjugates transport in prokaryotic cells, although many studies have been performed in eukary otic systems. This study demonstrates that glutathione S-conjugates (2 ,4-dinitrophenyl-S-glutathione and bimane-S-glutathione) are transport ed also out of Escherichia coli K12 cells. This transport is inhibited by vanadate, fluoride and other inhibitors of glutathione S-conjugate transport in mammalian cells suggesting a similarity of this process to that known in eukaryotes.