COST-EFFECTIVENESS OF TISSUE-PLASMINOGEN ACTIVATOR FOR ACUTE ISCHEMICSTROKE

Citation
Sc. Fagan et al., COST-EFFECTIVENESS OF TISSUE-PLASMINOGEN ACTIVATOR FOR ACUTE ISCHEMICSTROKE, Neurology, 50(4), 1998, pp. 883-890
Citations number
26
Categorie Soggetti
Clinical Neurology
Journal title
ISSN journal
00283878
Volume
50
Issue
4
Year of publication
1998
Pages
883 - 890
Database
ISI
SICI code
0028-3878(1998)50:4<883:COTAFA>2.0.ZU;2-N
Abstract
Tissue plasminogen activator (tPA) has been shown to improve 3-month o utcome in stroke patients treated within 3 hours of symptom onset. The costs associated with this new treatment will be a factor in determin ing the extent of its utilization. Data from the NINDS rt-PA Stroke Tr ial and the medical literature were used to estimate the health and ec onomic outcomes associated with using tPA in acute stroke patients, A Markov model was developed to estimate the costs per 1,000 patients el igible for treatment with tPA compared with the costs per 1,000 untrea ted patients. One-way and multiway sensitivity analyses (using Monte C arlo simulation) were performed to estimate the overall uncertainty of the model results. In the NINDS rt-PA Stroke Trial, the average lengt h of stay was significantly shorter in tPA-treated patients than in pl acebo-treated patients (10.9 versus 12.4 days; p = 0.02) and more tPA patients were discharged to home than to inpatient rehabilitation or a nursing home (48% versus 36%; p = 0.002), The Markov model estimated an increase in hospitalization costs of $1.7 million and a decrease in rehabilitation costs of $1.4 million and nursing home cost of $4.8 mi llion per 1,000 eligible treated patients for a health care system tha t includes acute through long-term care facilities, Multiway sensitivi ty analysis revealed a greater than 90% probability of cost savings. T he estimated impact on long-term health outcomes was 564 (3 to 850) qu ality-adjusted life-years saved over 30 years of the model per 1,000 p atients. Treating acute ischemic stroke patients with tPA within 3 hou rs of symptom onset improves functional outcome at 3 months and is lik ely to result in a net cost savings to the health care system.