Tissue plasminogen activator (tPA) has been shown to improve 3-month o
utcome in stroke patients treated within 3 hours of symptom onset. The
costs associated with this new treatment will be a factor in determin
ing the extent of its utilization. Data from the NINDS rt-PA Stroke Tr
ial and the medical literature were used to estimate the health and ec
onomic outcomes associated with using tPA in acute stroke patients, A
Markov model was developed to estimate the costs per 1,000 patients el
igible for treatment with tPA compared with the costs per 1,000 untrea
ted patients. One-way and multiway sensitivity analyses (using Monte C
arlo simulation) were performed to estimate the overall uncertainty of
the model results. In the NINDS rt-PA Stroke Trial, the average lengt
h of stay was significantly shorter in tPA-treated patients than in pl
acebo-treated patients (10.9 versus 12.4 days; p = 0.02) and more tPA
patients were discharged to home than to inpatient rehabilitation or a
nursing home (48% versus 36%; p = 0.002), The Markov model estimated
an increase in hospitalization costs of $1.7 million and a decrease in
rehabilitation costs of $1.4 million and nursing home cost of $4.8 mi
llion per 1,000 eligible treated patients for a health care system tha
t includes acute through long-term care facilities, Multiway sensitivi
ty analysis revealed a greater than 90% probability of cost savings. T
he estimated impact on long-term health outcomes was 564 (3 to 850) qu
ality-adjusted life-years saved over 30 years of the model per 1,000 p
atients. Treating acute ischemic stroke patients with tPA within 3 hou
rs of symptom onset improves functional outcome at 3 months and is lik
ely to result in a net cost savings to the health care system.