PREPARATION OF CHIRAL STATIONARY PHASES C OATED USING CELLULOSE DERIVATIVES AND STUDY OF CHIRAL RESOLUTION IN HPLC

Optical resolution of a range of racemic compounds was investigated us ing cellulose tribenzate and trisphenylcarbamate coated onto a small-p artial spherical organosilane-modified silica. The influence on chiral discrimination of factors such as coated loadings and mobile phase wa s performed. The loadings of 15% on the support gave the best results. The regioselectivity of an asymmetric hydroesterification of styrene was determined by HPLC using a chiral stationary phase(CTPC-CSP). A sa tisfactory result had been obtained on CTPC chiral column with n-hexan e/2-propanol (98/2 in volume ratio) as mobile phase.