Nineteen children with epilepsy were tested on two occasions, first du
ring treatment with carbamazepine (CBZ) and then 6 months later withou
t treatment. Plasma drug concentrations were within the therapeutic li
mits in all children. The children were examined with a standardized t
est of gross- and fine- motor functions, the Bruininks-Oseretsky test
of motor proficiency. Significant improvements were found in response
speed(p < 0.05), in composite fine-motor tests (p < 0.01) and in the t
otal test battery (p < 0.05) after the treatment had been withdrawn. A
tendency to improvement was found in the fine-motor subtest of upper
limb coordination (p = 0.08). Another group of 12 children was tested
twice during treatment with CBZ with an interval of 6 months. No diffe
rence was found in this group except for an impairment of the results
in the subtest of visual-motor control on the second test occasion (p
= 0.05).