ANTITUMOR-ACTIVITY OF CONJUGATES OF THE ONCOFETAL PROTEIN ALPHA-FETOPROTEIN AND PHTHALOCYANINES IN-VITRO

The several conjugates of aluminium and cobalt complexes of phthalocya nines with human alpha-fetoprotein have been synthesized. Their cytoto xic activity against tumor cells and human peripheral blood lymphocyte s was studied. The experimental data demonstrate that the cytotoxic ac tivity of alpha-fetoprotein-phthalocyanine conjugates against three ty pes of tumor cells of various origin is much higher (for aluminium and cobalt complexes more than 1000 and 50 times, respectively) in compar ison with phthalocyanines themselves. The application of phthalocyanin es as conjugates with alpha-fetoprotein makes it possible to markedly enhance the selective toxicity of phthalocyanines against human tumor cells.