The problem of meeting the normative demands of two cultures (host cou
ntry and country of origin) has been linked to adolescent substance us
e as a way to cope with conflicts with parents. This paper examines in
tergenerational conflict as a precursor to alcohol, tobacco, and other
drug use among second-generation Asian-Indian adolescents (Asian Amer
icans whose parents emigrated from India). Based on systems theory, a
structural model depicting linkage and temporal sequelae of mediating
factors is presented. Risk protective factors unique to Asian-Indian a
dolescents-sociodemographic, family relationship, peer bonding, psycho
logical, cultural, and ecological-are identified. Further, the impact
of gender differences on family relationships is examined. Implication
s of the findings for drug use prevention policies, with special empha
sis on developing comprehensive primary prevention strategies, are dis
cussed.