To assess the clinical effectiveness of glaucoma therapy with diode la
ser cyclophotocoagulation, 106 eyes (51 eyes with primary open-angle g
laucoma, 22 eyes with secondary glaucoma, 10 eyes with narrow-angle gl
aucoma, 23 eyes with other glaucomas) of 87 patients were treated. Usi
ng a diode laser coupled with a fiberoptic probe, ending in a focusing
tip, all eyes were treated with 24-30 spots over 360 degrees and 2.8-
3.6 J of energy, 1.5 mm posterior to the limbus. The intraocular press
ure was obtained over a period of time until 8-24 months after operati
on. Additionally, morphological changes of the ciliary body were obser
ved in 25 eyes by means of ultrasound biomicroscopy. Results: The IOP
decreased from a baseline mean of 25.0 +/- 5.7 mm Hg to 17.6 +/- 5.3 m
m Hg directly after operation and increased slightly to 18.0 +/- 6.0 m
m Hg in the following 24 months. Successful control of IOP (IOP consta
ntly < 22 mm Hg or pain relief in blind eyes) occurred in 90 of 106 ey
es (84.9%). In 23 eyes more than one treatment was given. In 6 eyes an
other IOP-reducing operation had to be performed. In 19 eyes slightly
elongated intraocular inflammatory reactions were seen, without any se
rious complications. The morphological investigations showed in 22 of
25 cases temporary edema of the ciliary body. A temporary detachment o
f the ciliary body was seen in 8 eyes. Conclusions: Diode laser cyclop
hotocoagulation is an effective and safe procedure to reduce IOP in di
fferent types of glaucoma over a long time. Postoperatively, a tempora
ry inflammatory reaction of the ciliary body was observed with no corr
elation to the degree of reduction of the IOP.