SCHISTOSOMA-HAEMATOBIUM, SCHISTOSOMA-INTERCALATUM, SCHISTOSOMA-JAPONICUM, SCHISTOSOMA-MANSONI, AND S-RODHAINI IN MICE - RELATIONSHIP BETWEEN PATTERNS OF LUNG MIGRATION BY SCHISTOSOMULA AND PERFUSION RECOVERY OF ADULT WORMS

The development of five schistosome species was compared in mice by th e recovery of schistosomula from chopped lung tissue and of adult worm s by portal perfusion. Three developmental patterns appeared. (1) Schi stosoma japonicum was unique in showing an early establishment of schi stosomula in and a rapid departure from the lungs together with the hi ghest worm recovery, (2) S. haematobium contrasted by establishing lat er and persisting in the lungs for at least 2 weeks while yielding the lowest adult worm recovery; and (3) S. intercalatum, S. mansoni, and S. rodhaini had an intermediate pattern - they resided in the lungs fo r several days, then disappeared and produced intermediate numbers of adults. Lung petechiae, known to accompany the migration of S. japonic um, were never detected after infection with the other species. We spe culate that the three migration patterns of schistosomes are related t o the size of the relative spectra of naturally infected definitive ho sts.