MOLECULAR RECOGNITION STUDY ON A SUPRAMOLECULAR SYSTEM (VIII) - THE FLUOROSCOPIC STUDY ON INCLUSION COMPLEXATION OF ADAMANTANOL WITH CYCLODEXTRIN DERIVATIVES

The fluorescence spectral titrations have been performed in phosphate buffer solution (pH 7.2) at room temperature to give the stability con stants for inclusion complexation of a series of chemically modified b eta-cyclodextrins bearing aromatic groups with adamantanol. The molecu lar recognition mechanism is discussed from the viewpoint of the struc tural factors, electron effect of the substitutent groups and the size and chain length of the fluorophore. The results indicate that the co mplex stability of the cyclodextrin derivatives bearing a positively c harged pyridinio moiety can be enhanced by the electrostatic interacti on between the host cyclodextrins and the adamantanol guest and the mi croenvironment change plays a crucial role in the inclusion complexati on.